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- Title
T cell receptor polymorphisms in Caucasians and Polynesians.
- Authors
Abbott, W. G. H.; Tan, P. L. J.; Skinner, M. A.; Marbrook, J.; Peake, J. S.; Woodfield, D. G.; Geursen, A.
- Abstract
The purpose of this study was to find genetic polymorphisms that might be useful in studies of Polynesian-Caucasian racial admixture and Polynesian disease susceptibility. The allele frequencies of six T cell receptor locus RFLP were measured in 73 Caucasians and two Polynesian ethnic groups comprising 86 Maoris and 95 Samoans. The RFLP studied were (locus/enzyme/probe): Cα/Taq1/Y14, Vα/Taq1/Y14, Cβ/BglII/Y35, Cγ/PvuII/HGP02, Vβ7/BamHI/Vβ7.4 and Vβ8/ Bam HI/Vβ8.1. Racial differences in allele frequency were present with all six RFLP (P < 0.001). The allele frequencies of the Vα/Taq1/Y14 and the Vβ7/Bam HI/7.4 RFLP were similar in the two Polynesian groups, both of which differed from the Caucasians. The 1.4 kb allele of the Vα/Taq1/Y14 RFLP and the 8.0 kb allele of the Vβ`7/Bam HI/7.4 RFLP were present in low frequency in both Polynesian groups compared to the Caucasian group, consistent with a gene flow effect. These alleles may be useful in studies of Caucasian-Polynesian racial admixture.
- Subjects
T cell receptors; GENETIC polymorphisms; CELL receptors; CAUCASIAN race; POLYNESIANS; POPULATION genetics
- Publication
Immunology & Cell Biology, 1993, Vol 71, Issue 6, p543
- ISSN
0818-9641
- Publication type
Article
- DOI
10.1038/icb.1993.60