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- Title
SARS-CoV-2 Spike S1-specific IgG kinetic profiles following mRNA or vector-based vaccination in the general Dutch population show distinct kinetics.
- Authors
van den Hoogen, Lotus L.; Verheul, Marije K.; Vos, Eric R. A.; van Hagen, Cheyenne C. E.; van Boven, Michiel; Wong, Denise; Wijmenga-Monsuur, Alienke J.; Smits, Gaby; Kuijer, Marjan; van Rooijen, Debbie; Bogaard-van Maurik, Marjan; Zutt, Ilse; van Vliet, Jeffrey; Wolf, Janine; van der Klis, Fiona R. M.; de Melker, Hester E.; van Binnendijk, Robert S.; den Hartog, Gerco
- Abstract
mRNA- and vector-based vaccines are used at a large scale to prevent COVID-19. We compared Spike S1-specific (S1) IgG antibodies after vaccination with mRNA-based (Comirnaty, Spikevax) or vector-based (Janssen, Vaxzevria) vaccines, using samples from a Dutch nationwide cohort. In adults 18–64 years old (n = 2412), the median vaccination interval between the two doses was 77 days for Vaxzevria (interquartile range, IQR: 69–77), 35 days (28–35) for Comirnaty and 33 days (28–35) for Spikevax. mRNA vaccines induced faster inclines and higher S1 antibodies compared to vector-based vaccines. For all vaccines, one dose resulted in boosting of S1 antibodies in adults with a history of SARS-CoV-2 infection. For Comirnaty, two to four months following the second dose (n = 196), S1 antibodies in adults aged 18–64 years old (436 BAU/mL, IQR: 328–891) were less variable and median concentrations higher compared to those in persons ≥ 80 years old (366, 177–743), but differences were not statistically significant (p > 0.100). Nearly all participants seroconverted following COVID-19 vaccination, including the aging population. These data confirm results from controlled vaccine trials in a general population, including vulnerable groups.
- Subjects
IMMUNOGLOBULIN G; VACCINATION; SARS-CoV-2; OLDER people; VACCINE trials
- Publication
Scientific Reports, 2022, Vol 12, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-022-10020-6