We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Role of Polyamines and Hypusine in β Cells and Diabetes Pathogenesis.
- Authors
Kulkarni, Abhishek; Anderson, Cara M.; Mirmira, Raghavendra G.; Tersey, Sarah A.
- Abstract
The polyamines—putrescine, spermidine, and spermine—are polycationic, low molecular weight amines with cellular functions primarily related to mRNA translation and cell proliferation. Polyamines partly exert their effects via the hypusine pathway, wherein the polyamine spermidine provides the aminobutyl moiety to allow posttranslational modification of the translation factor eIF5A with the rare amino acid hypusine (hydroxy putrescine lysine). The "hypusinated" eIF5A (eIF5Ahyp) is considered to be the active form of the translation factor necessary for the translation of mRNAs associated with stress and inflammation. Recently, it has been demonstrated that activity of the polyamines-hypusine circuit in insulin-producing islet β cells contributes to diabetes pathogenesis under conditions of inflammation. Elevated levels of polyamines are reported in both exocrine and endocrine cells of the pancreas, which may contribute to endoplasmic reticulum stress, oxidative stress, inflammatory response, and autophagy. In this review, we have summarized the existing research on polyamine-hypusine metabolism in the context of β-cell function and diabetes pathogenesis.
- Subjects
POLYAMINES; ORNITHINE decarboxylase; POST-translational modification; SPERMIDINE; SPERMINE; CELL physiology; PATHOGENESIS; ISLANDS of Langerhans
- Publication
Metabolites (2218-1989), 2022, Vol 12, Issue 4, pN.PAG
- ISSN
2218-1989
- Publication type
Article
- DOI
10.3390/metabo12040344