We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Mathematical Modelling of Enfuvirtide and Protease Inhibitors as Combination Therapy for HIV.
- Authors
Chowdhury, Sonia; Roy, Priti Kumar; Smith?, Robert J.
- Abstract
Enfuvirtide (formerly T20) is an injectable fusion inhibitor that has established effective antiretroviral activity and excellent tolerability in extensively pretreated patients. This fusion inhibitor does not affect the metabolism of other co-administrated drugs for metabolic drug interactions involving enfuvirtide. Few mathematical models have considered co-administration of antiretroviral drugs. We develop a mathematical model to study the effect of enfuvirtide upon this process in combination with protease inhibitors (PIs) using impulsive differential equations. We divide the T cells into several classes to describe the drug activity. Analytical results show that a combination of enfuvirtide and PIs gives a better outcome than single drug activity; furthermore, use of enfuvirtide clearly outranks PIs if only one class of drugs were to be used. We determine the threshold value for the dosage and dosing intervals to ensure the stability of the disease-free state and illustrate our results with numerical simulations. We recommend that use of enfuvirtide, in combination with PIs, be expanded beyond salvage therapy.
- Subjects
MATHEMATICAL models; ENFUVIRTIDE (Drug); HIV fusion inhibitors; ANTI-HIV agents; PROTEASE inhibitors
- Publication
International Journal of Nonlinear Sciences & Numerical Simulation, 2016, Vol 17, Issue 6, p259
- ISSN
1565-1339
- Publication type
Article
- DOI
10.1515/ijnsns-2015-0051