We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
IGFBP-1 is expressed specifically in ovarian clear cell adenocarcinoma.
- Authors
Sugita, Shintaro; Morishita, Yukio; Kano, Junko; Furuya, Shuichiro; Shiba-Ishii, Aya; Noguchi, Masayuki
- Abstract
Sugita S, Morishita Y, Kano J, Furuya S, Shiba-Ishii A & Noguchi M (2011) Histopathology, 729-738 To investigate the specific expression of insulin-like growth factor binding protein-1 (IGFBP-1) in ovarian clear cell adenocarcinoma (CCA). Immunohistochemistry and in situ hybridization for IGFBP-1 were performed in normal endometrium, placenta, and 100 surgically resected cases of ovarian cancer including 31 CCAs and 69 non-CCAs. Immunohistochemistry for hepatocyte nuclear factor-1 (HNF-1β) was also examined in all cases. Specific expression of IGFBP-1 was confirmed in secretory endometrium, decidua of placenta and Arias-Stella glands of miscarriage material. Among ovarian cancers, almost all cases of CCA showed expression of both IGFBP-1 protein and mRNA, but non-CCA hardly expressed IGFBP-1. There was a significant difference between CCA and non-CCA in the expression of IGFBP-1 protein and mRNA. No correlation was found between the rate of IGFBP-1 expression and pathological T and N factors of the tumour-node-metastasis (TNM) classification. All CCA cases except for one exhibited expression of HNF-1β protein, whereas only 15.9% of non-CCAs did so. The expression of IGFBP-1 in CCA is more specific than that of HNF-1β. IGFBP-1 shows expression by decidual endometrium and Arias-Stella glands, and CCA also exhibits characteristic expression. These results indicate that IGFBP-1 is a immunohistochemical marker for CCA.
- Subjects
RENAL cell carcinoma; OVARIAN cancer; INSULIN-like growth factor-binding proteins; DIAGNOSTIC immunohistochemistry; DIAGNOSTIC use of in-situ hybridization; HEPATOCYTE growth factor; METASTASIS
- Publication
Histopathology, 2011, Vol 58, Issue 5, p729
- ISSN
0309-0167
- Publication type
Article
- DOI
10.1111/j.1365-2559.2011.03817.x