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- Title
Imbalance of CD4<sup>+</sup> CD45R<sup>+</sup> and CD4<sup>+</sup> CD29<sup>+</sup> T helper cell subsets in patients with atopic diseases.
- Authors
Schauer, U.; Jung, T.; Heymanns, J.; Rieger, H. L.
- Abstract
To evaluate the proportion of helper cell subsets we studied 18 children with atopic dermatitis, 30 patients with asthma, 27 healthy age-matched controls aged 1 to 17 years and 11 atopic controls without symptoms related to atopy, aged 9-22 years. Lymphocytes were isolated from heparinized peripheral blood and the proportion of CD4+CD29+ and CD4+CD45R+ cells was determined by double-labelling immunofluorescence. Children with atopic dermatitis yielded a significantly (P < 0.01) higher proportion of CD4+CD45R+ (median 75%) cells compared with normal controls (median 66.6%), whereas the proportion of CD4+CD29+ cells was significantly (P < 0.001) lower in patients with atopic dermatitis (median 20.4 versus 29.6%). Interestingly, the percentage of CD4+CD45R+ cells shows an age-dependent decline (r = -0.67, P < 0.01) in the control group., which is not found in the patient group.
- Subjects
ATOPIC dermatitis; SKIN inflammation; ALLERGIES; ASTHMA; LYMPHOCYTES; CELLS
- Publication
Clinical & Experimental Immunology, 1991, Vol 83, Issue 1, p25
- ISSN
0009-9104
- Publication type
Article