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- Title
Relationship Between Short-Term Blood Pressure Variability and Incidence of Acute Kidney Injury in Critically Ill Patients.
- Authors
Xie, Zhichao; Liao, Xuelian; Yin, Wanhong; Kang, Yan; Guo, Jun; Lu, Meizhu
- Abstract
Background/Aims: Blood pressure (BP) variability is associated with cardiovascular events, and cerebral and renal damage. The aim of this study was to investigate any potential relationship between short-term BP variability and incidence of acute onset conditions, such as acute kidney injury (AKI), in critically ill patients. Methods: BP was monitored to analyze its variability in critically ill patients in present study. Short-term BP variability was assessed as average real variability (ARV), standard deviation (SD) and coefficient of variation (CV) of 24-hour BP. Results: A total of 565 patients were included, 41.2% (n=233) of which presented with AKI after admission (AKI stage I, n = 94; stage II, n = 37; stage III, n = 102). The mean APACHE II score was 21.5 for all patients. ARV of 24 h systolic BP was significantly higher in patients with AKI (p<0.001). This association remained (p=0.006) after adjustment for potential confounders. The incidence of AKI increased with the ARV from 14.0% (ARV ≤6 mmHg) to 73.9% (ARV >14 mmHg). A weak association was also found between BP variability and hospital mortality in critically ill patients. Conclusion: BP variability is correlated with the incidence of AKI in critically ill patients.
- Subjects
BLOOD pressure; KIDNEY injuries; STANDARD deviations; MORTALITY; DIFFERENCES
- Publication
Kidney & Blood Pressure Research, 2018, Vol 42, Issue 6, p1238
- ISSN
1420-4096
- Publication type
Article
- DOI
10.1159/000485927