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- Title
Oral Bicarbonate Slows Decline of Residual Renal Function in Peritoneal Dialysis Patients.
- Authors
Liu, Xiang-Yang; Gao, Xiu-Mei; Zhang, Ning; Chen, Rui; Wu, Feng; Tao, Xin-Chao; Li, Chun-Jun; Zhang, Ping; Yu, Pei
- Abstract
Background/Aims: Metabolic acidosis is a common consequence of end- stage renal disease (ESRD) which may result in a substantial adverse outcome. The effect of oral bicarbonate on the preservation of residual renal function (RRF) in peritoneal dialysis (PD) patients has been rarely reported. Methods: We randomly assigned 40 continuous ambulatory peritoneal dialysis (CAPD) patients to the oral bicarbonate group or placebo group at a 1:1 ratio. All enrollments were followed for a duration of 104 weeks. We took residual creatinine clearance (CCr), a measure of residual renal function (RRF), as the primary outcome. Residual CCr was calculated as the average of urea and creatinine clearance from a 24-hour urine collection. Results: Thirteen patients in the placebo group and 15 patients in the treatment group completed the 104 weeks of follow-up with a comparable dropout rate (placebo group: 35% vs treatment group: 25%). Compared with the placebo group, serum bicarbonate in treatment group was significantly increased at each time point and oral bicarbonate resulted in a slower declining rate of residual CCr (F=5.113, p=0.031). Baseline residual CCr at enrollment also had a significant effect on residual CCr (F=168.779, P<0.001). Charlson Comorbidity Index which was adopted to calculate a comorbidity score had no significant effect on residual CCr loss (F=0.168, P=0.685). Conclusion: Oral bicarbonate may have a RRF preserving effect in CAPD patients, and a normal to high level of serum bicarbonate (⩾24mmol/L) may be appropriate for RRF preservation.
- Subjects
ACIDOSIS; CHRONIC kidney failure; BICARBONATE ions; KIDNEY diseases; PERITONEAL dialysis; CREATININE
- Publication
Kidney & Blood Pressure Research, 2017, Vol 42, Issue 3, p565
- ISSN
1420-4096
- Publication type
Article
- DOI
10.1159/000479641