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- Title
Call for morphological detection of Charcot‐Leyden crystals in tissue.
- Authors
Bai, Yurong; Chen, Wenyi; Kong, Weifeng; Luo, Xin; Chen, Jingyuan; Wang, Xinyue; Wu, Qingwu; Chen, Jianning; Yang, Qintai; Zhang, Yana
- Abstract
Keywords: CLCs; CRSwNP; ENT; immunology; morphology EN CLCs CRSwNP ENT immunology morphology 1 3 3 07/26/23 20230701 NES 230701 To the editor, We thank Dr. Sasaki, Dr. Suzaki, and Dr. Ueki for their interest and comments on the letter entitled "Predictive significance of Charcot-Leyden crystal structures for nasal polyp recurrence",[1] which raises several important points. Despite both hematoxylin and eosin (H&E) staining and immunofluorescence (IF) histochemistry are methods for detecting crystalline CLCs, IF staining has long been supposed to have better efficiency and specificity in displaying crystalline CLCs morphology. Both data from us and others have demonstrated that CLCs serve as biomarkers for diagnosing eosinophilic chronic rhinosinusitis with nasal polyps (NPs) and predicting NP recurrence.[[1]] Although CLC protein has three distinct forms, including extracellular vesicles, extracellular soluble protein and crystalline CLC structures (CLCs), only crystalline CLCs could drive type 2 inflammation and allergic immunity.[[3]] Therefore, we think that detecting crystalline CLCs in tissue is crucial and meaningful.
- Subjects
CRYSTALS; NASAL mucosa; HEMATOXYLIN &; eosin staining
- Publication
Clinical & Translational Allergy, 2023, Vol 13, Issue 7, p1
- ISSN
2045-7022
- Publication type
Article
- DOI
10.1002/clt2.12276