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- Title
Amino acid position 37 of HLA-DRβ1 affects susceptibility to Crohn's disease in Asians.
- Authors
Han, Buhm; Akiyama, Masato; Kim, Kyung-Kon; Oh, Hyunjung; Choi, Hyunchul; Lee, Cue Hyunkyu; Jung, Seulgi; Lee, Ho-Su; Kim, Emma E; Cook, Seungho
- Abstract
Crohn's disease (CD) and ulcerative colitis (UC) are the major types of chronic inflammatory bowel disease (IBD) characterized by recurring episodes of inflammation of the gastrointestinal tract. Although it is well established that human leukocyte antigen (HLA) is a major risk factor for IBD, it is yet to be determined which HLA alleles or amino acids drive the risks of CD and UC in Asians. To define the roles of HLA for IBD in Asians, we fine-mapped HLA in 12 568 individuals from Korea and Japan (3294 patients with CD, 1522 patients with UC and 7752 controls). We identified that the amino acid position 37 of HLA-DRβ1 plays a key role in the susceptibility to CD (presence of serine being protective, P = 3.6 × 10−67, OR = 0.48 [0.45–0.52]). For UC, we confirmed the known association of the haplotype spanning HLA-C*12:02, HLA-B*52:01 and HLA-DRB1*1502 (P = 1.2 × 10−28, OR = 4.01 [3.14–5.12]).
- Publication
Human Molecular Genetics, 2018, Vol 27, Issue 22, p3901
- ISSN
0964-6906
- Publication type
Article
- DOI
10.1093/hmg/ddy285