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- Title
Prevalence of cytotoxin-associated genes of Helicobacter pylori among Iranian GERD patients.
- Authors
Shavalipour, Aref; Malekpour, Habib; Dabiri, Hossein; Kazemian, Hossein; Zojaji, Homayon; Bahroudi, Mahboube
- Abstract
Aim: Since the impact of H. pylori and its virulence is not clear in GERD, this study aimed to evaluate the prevalence of cag A and cag E gens of H. pylori among Iranian GERD patients. Background: Gastroesophageal reflux disease (GERD) is defined as a condition of reflux the stomach juice by low pH causes tissue damage. Helicobacter pylori may or may not influence the GERD; however, it is unclear. Methods: This study was a case-control study performed on patients with GERD who underwent upper gastrointestinal endoscopy at Taleghani Hospital of Tehran, Iran. Prevalence of H. pylori and presence of the cag A and cag E genes in GERD and control group was investigated. Results: H. pylori was detected in 54% and 62% of GERD and control groups respectively. Prevalence of cag A gene among GERD patients was 44.4% whereas among the control group it was 87%. Prevalence of the cag E among GERD patients and control group was 44.4% and 64% respectively. Coexistence of cag A and cag E in GERD patients was 25.7% and in the control patients it was 54.8%. Conclusion: We did not find correlation between H. pylori existence in GERD patients in comparison to the control group. Similar to other Asian studies, the presence of the cag A in control group was more than GERD patients significantly. The co-existence of cag A and cag E was also more in control group significantly.
- Subjects
IRAN; GASTROESOPHAGEAL reflux diagnosis; HELICOBACTER disease diagnosis; GASTROESOPHAGEAL reflux; GENES; HELICOBACTER pylori; HOSPITALS; CONTROL groups; DISEASE prevalence; CASE-control method; CYTOTOXINS; ENDOSCOPIC gastrointestinal surgery
- Publication
Gastroenterology & Hepatology from Bed to Bench, 2017, Vol 10, Issue 3, p178
- ISSN
2008-2258
- Publication type
Article