We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Emergence of Crimean–Congo Hemorrhagic Fever Virus in Eastern Senegal in 2022.
- Authors
Sene, Ousseynou; Sagne, Samba Niang; Ngom, Déthié; Diagne, Moussa Moise; Badji, Aminata; Khoulé, Aliou; Ndiaye, El Hadji; Sankhe, Safietou; Loucoubar, Cheikh; Diallo, Mawlouth; Weidmann, Manfred; Dia, Ndongo; Simon-Lorière, Etienne; Sall, Yoro; Diop, Boly; Ndiaye, Mamadou; Sakuntabhai, Anavaj; Sall, Amadou Alpha; Faye, Ousmane; Faye, Oumar
- Abstract
Crimean–Congo hemorrhagic fever (CCHF), the most widespread tick-borne viral human infection, poses a threat to global health. In this study, clinical samples collected through national surveillance systems were screened for acute CCHF virus (CCHFV) infection using RT-PCR and for exposure using ELISA. For any CCHF-positive sample, livestock and tick samples were also collected in the neighborhood of the confirmed case and tested using ELISA and RT-PCR, respectively. Genome sequencing and phylogenetic analyses were also performed on samples with positive RT-PCR results. In Eastern Senegal, two human cases and one Hyalomma tick positive for CCHF were identified and a seroprevalence in livestock ranging from 9.33% to 45.26% was detected. Phylogenetic analyses revealed that the human strain belonged to genotype I based on the available L segment. However, the tick strain showed a reassortant profile, with the L and M segments belonging to genotype I and the S segment belonging to genotype III. Our data also showed that our strains clustered with strains isolated in different countries, including Mauritania. Therefore, our findings confirmed the high genetic variability inside the CCHF genotypes and their introduction to Senegal from other countries. They also indicate an increasing CCHF threat in Senegal and emphasize the need to reinforce surveillance using a one-health approach.
- Subjects
SENEGAL; MAURITANIA; HEMORRHAGIC fever; GENETIC variation; RANGELANDS; RIFT Valley fever; NUCLEOTIDE sequencing; SEQUENCE analysis; TICK infestations
- Publication
Viruses (1999-4915), 2024, Vol 16, Issue 2, p315
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v16020315