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- Title
Dermatological Adverse Events Associated with Topical Brimonidine Gel 0.33% in Subjects with Erythema of Rosacea A Retrospective Review of Clinical Studies.
- Authors
HOLMES, ANNA D.; WAITE, KIMBERLY A.; CHEN, MICHAEL C.; PALANISWAMY, KIRUTHI; WISER, THOMAS H.; DRAELOS, ZOE D.; RAFAL, ELYSE S.; WERSCHLER, PHILIP; HARVEY, ALISON E.
- Abstract
Background: The topical a2 adrenergic receptor agonist brimonidine gel 0.33% is an effective and safe pharmacological treatment for the facial erythema of rosacea. However, adverse events of worsened redness have occasionally been reported with its use. Objective: A detailed analysis of adverse events is needed to accurately define worsening erythema and the adverse-events profile associated with brimonidine gel treatment. Methods and measurements: A retrospective review of related dermatological adverse events occurring in subjects enrolled in the two pivotal four-week Phase 3 studies and the 52-week long-term safety study for brimonidine gel was conducted. Measurements included total adverse-event incidences; number of subjects experiencing adverse events; study discontinuation due to adverse events, severity, onset, episodic duration period; and correlation of adverse events to subject disposition, and rosacea profile. Results: Flushing and erythema were the most commonly reported adverse events, occurring in a total of 5.4 percent of subjects in the Phase 3 studies and in 15.4 percent in the long-term study. Most adverse events were mild or moderate in severity, transient, and intermittent. Adverse events occurred early in treatment, and duration was short-lived in the majority of cases. Adverse-event patterns were not remarkably altered with regard to subject disposition in the long-term study. Conclusion: Adverse events of worsening redness are not frequent, are transient in nature, and occur early in the course of treatment with brimonidine gel.
- Subjects
DRUG side effects; ADRENERGIC agonists; ERYTHEMA; ROSACEA; BLUSHING; THERAPEUTICS
- Publication
Journal of Clinical & Aesthetic Dermatology, 2015, Vol 8, Issue 8, p29
- ISSN
1941-2789
- Publication type
Article