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- Title
Magnetic resonance imaging: Making sense of disassembly.
- Authors
Azagarsamy, Malar A.; Thayumanavan, S.
- Abstract
The article discusses the report presented by Itaru Hamachi and colleagues from Kyoto University in Japan on a new approach concerning the generation of well-defined spectroscopic signatures to signal a specific ligand-receptor binding event. The team devised a strategy for protein sensing that utilizes well-known ligands that are complementary to specific proteins to be incorporated into an amphiphilic molecule that also contains trifluoromethyl groups as a spectroscopic tag indicating the disassembly of nanostructures when the complementary protein is added to the solution. The team used the disassembly event for the generation of nuclear magnetic resonance (NMR) signals in solution and demonstration of its utility in magnetic resonance imaging (MRI) in live cells.
- Subjects
JAPAN; HAMACHI, Itaru; MAGNETIC resonance imaging; NUCLEAR magnetic resonance; NANOSTRUCTURES; SPECTROSCOPIC imaging; LIGANDS (Chemistry); RECEPTOR-ligand complexes; KYOTO Daigaku
- Publication
Nature Chemistry, 2009, Vol 1, Issue 7, p523
- ISSN
1755-4330
- Publication type
Article
- DOI
10.1038/nchem.383