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- Title
PSA Bounce Phenomenon after LDR Brachytherapy Using Permanent <sup>125</sup>Iodine Seeds Implantation.
- Authors
Dudu, C.; Hârza, M.; Toader, C.; Hăineală, B.; Preda, A.; Domnişor, L.; Baston, C.; Rădulescu, M. F.; Sinescu, I.
- Abstract
Introduction and Objectives. Prostate-specific antigen levels after brachytherapy may fluctuate and increase temporarily without a clear reason in some of the successfully treated men. The phenomenon is called "PSA bounce" and it was first described in 1997 by Wallner et al. The purpose of the study is to evaluate PSA levels at the 60 month follow-up after prostate brachytherapy - permanent prostate implant with 125I, for patients with and without PSA bounce phenomenon. Materials and Methods. Between October 2006 and December 2011, a total of 168 patients with prostate cancer were treated with permanent 125I implantation brachytherapy, in stage T1c-T2a. PSA bounce is defined as a temporary increase in PSA value followed by a consecutive decrease recorded with the same value before the increase or a lower value. Results. The average magnitude of the bounce was 0.8 ng/ml with values between 0.1 and 4.1 ng/ml. Mean time to bounce was 17 months. At the 60-month follow-up, 83% of patients had PSA values lower than 1 ng/mL and 17% higher than 1 ng/mL. Conclusions. A bounce definition of a rise ≥ 0.2 ng/mL is a reliable definition, to use as a threshold. PSA bounce is a common phenomenon after prostate brachytherapy and should be always considered whenever we have a patient with rising PSA after implant.
- Subjects
PROSTATE cancer treatment; RADIOISOTOPE brachytherapy; PROSTATE-specific antigen
- Publication
Romanian Journal of Urology, 2017, Vol 16, Issue 3, p26
- ISSN
1223-0650
- Publication type
Article