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- Title
Cu(I)-Catalyzed Asymmetric Cross-Coupling of N-Tosylhydrazones and Trialkylsilylethynes: Enantioselective Construction of C(sp)--C(sp³) Bonds.
- Authors
Wen-Dao Chu; Fangfang Guo; Lefei Yu; Junting Hong; Qianyi Liu; Fanyang Mo; Yan Zhang; Jianbo Wang
- Abstract
The first catalytic enantioselective C(sp)--C(sp³) cross-coupling reaction between N-tosylhydrazones and trialkylsilylethynes in the presence of Cu(I) salts and chiral phosphoramidite ligands was developed. A series of synthetically interesting, functionalized alkynes were obtained with moderate to good enantioselectivities (up to 83% ee). Cu(II) carbene migratory insertion is proposed to be the enantio-determining step.
- Subjects
CLOUD computing; ALKYNES; HYDROCARBONS; ARTIFICIAL intelligence; ENANTIOMERS analysis
- Publication
Chinese Journal of Chemistry, 2018, Vol 36, Issue 3, p217
- ISSN
1001-604X
- Publication type
Article
- DOI
10.1002/cjoc.201700633