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- Title
A complex variant t(3;15) (q26;q13) representing cryptic/masked acute promyelocytic leukaemia with a novel breakpoint of chromosome 15--a case report.
- Authors
Appachu, Sandhya; Obulareddy, Chintaparthi; Sirsath, Nagesh T.; Lakshmaiah, Kuntejowdahalli C.; Kumari, Prasanna
- Abstract
Acute promyelocytic leukaemia (APML) is a biologically and clinically distinct variant of AML, currently classified as acute myeloid leukaemia with recurrent cytogenetic anomalies t(15;17) (q22;q21), promyelocytic leukaemia-retinoic acid receptor alpha, diagnosis regardless of blast count in the World Health Organization classification system. It is one of the curable malignancies, has a unique clinical presentation, often with disseminated intravascular coagulation, and has a targeted therapy for its treatment in the form of all trans retinoic acid (ATRA) and arsenic trioxide (ATO). Here, we report a complex type of variant APML t(3;15) (q26;q13), the need for conventional karyotyping for diagnosing such rare variants, and its response to ATRA and ATO.
- Subjects
PRELEUKEMIA; CHROMOSOMES; CYTOGENETICS; DIAGNOSIS; WORLD Health Organization
- Publication
Ecancermedicalscience, 2013, Vol 7, Issue 334-360, p1
- ISSN
1754-6605
- Publication type
Case Study
- DOI
10.3332/ecancer.2013.340