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- Title
The effect of vitamin A and vitamin C on postoperative adhesion formation: A rat model study.
- Authors
Keleidari, Behrouz; Mahmoudieh, Mohsen; Bahrami, Faranak; Mortazavi, Pejman; Sari Aslani, Reza; Toliyat, Seyed Alireza
- Abstract
Background: The aim of this study is to investigate the effect of vitamin A and C, as the agents that improve wound healing, on the adhesion formation process. Materials and Methods: Sixty male Wistar rats were used. They underwent midline laparotomy, for repair of a peritoneal injury, and were then assigned to four groups. Group 1 (Vitamin A) received 2000 units/kg intramuscular injection of vitamin A daily, post surgery, for two weeks; Group 2 (Vitamin C) received 100 mg/kg oral vitamin C daily, after laparotomy, for two weeks; Group 3 (vitamins A and C) received 2000 units/kg intramuscular injection of vitamin A and 100 mg/kg oral vitamin C daily, after laparotomy, for two weeks, and Group four (Sham) rats did not receive any drugs. The adhesion, inflammation, fibrosis scores, and wound integrity were evaluated after two weeks. Results: Rats in the vitamin C group had the lowest mean adhesion formation score (1 ± 0.27) and the values of p were < 0.0001 for the vitamin A group and vitamin A and C groups and 0.003 for the sham group. Vitamin C also had the lowest fibrosis score (0.50 ± 0.17) among the study groups and the values of p were < 0.0001 for the vitamin A group and vitamin A and C groups and 0.002 for the sham group. The mean inflammation score did not differ significantly among the study groups. The wound disruption strength was the highest in the vitamin C group and the difference was statistically significant in the sham group (1188.69 ± 281.92 vs. 893.04 ± 187.46, p : 0.003). Conclusion: Administration of oral vitamin C reduces adhesion formation and improves wound healing.
- Subjects
SCARS; ANIMAL experimentation; BIOLOGICAL models; RATS; RESEARCH funding; STATISTICS; SURGICAL complications; OPERATIVE surgery; VITAMIN A; VITAMIN C; DATA analysis; DESCRIPTIVE statistics; PREVENTION
- Publication
Journal of Research in Medical Sciences, 2014, Vol 19, Issue 1, p28
- ISSN
1735-1995
- Publication type
Article