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- Title
OVEREXPRESSION OF DIFFERENT MEMBERS OF THE TYPE 1 GROWTH FACTOR RECEPTOR FAMILY AND THEIR ASSOCIATION WITH CELL PROLIFERATION IN PERIAMPULLARY CARCINOMA.
- Authors
VAIDYA, PRADEEP; KAWARADA, YOSHIFUMI; HIGASHIGUCHI, TAKASHI; YOSHIDA, TOSHIMICHI; SAKAKURA, TERUYO; YATANI, RYUICHI
- Abstract
The expression of epidermal growth factor receptor (EGFR), c- erbB-2, and c- erbB-3 was examined immunohistochemically in 57 cases of periampullary carcinoma. The percentage of Ki-67-positive cells was also examined in the same tissue, to determine the relationship between the expression of the members of the type 1 growth factor receptor family and cell proliferation. In carcinoma of the head of pancreas, the percentage of cases with overexpression of c- erbB-3 was significantly higher than with overexpression of c- erbB-2 and EGFR. In contrast, in lower bile duct carcinoma and carcinoma of the ampulla of Vater, the percentages of cases with overexpression of c- erbB-2 was greater than with overexpression of other growth factor receptors. A higher percentage of cases with overexpression of c- erbB-3 in pancreatic head carcinoma and overexpression of c- erbB-2 in carcinoma of the ampulla of Vater was found in Ki-67 antigen-positive cases. Moreover, the overexpression of c- erb-3 in pancreatic head carcinoma, c- erb-2 in ampulla of Vater carcinoma, and Ki-67 in both carcinomas was found to be associated with poor patient outcome. These results demonstrate that different members of the type 1 growth factor receptor family are overexpressed in different carcinomas of the periampullary region.
- Publication
Journal of Pathology, 1996, Vol 178, Issue 2, p140
- ISSN
0022-3417
- Publication type
Article
- DOI
10.1002/(SICI)1096-9896(199602)178:2<140::AID-PATH450>3.0.CO;2-U