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- Title
Ebola Virus Disease in Pregnancy: Clinical, Histopathologic, and Immunohistochemical Findings.
- Authors
Muehlenbachs, Atis; de la Rosa Vázquez, Olimpia; Bausch, Daniel G.; Schafer, Ilana J.; Paddock, Christopher D.; Nyakio, Jean Paul; Lame, Papys; Bergeron, Eric; McCollum, Andrea M.; Goldsmith, Cynthia S.; Bollweg, Brigid C.; Prieto, Miriam Alía; Lushima, Robert Shongo; Ilunga, Benoit Kebela; Nichol, Stuart T.; Wun-Ju Shieh; Ströher, Ute; Rollin, Pierre E.; Zaki, Sherif R.; Shieh, Wun-Ju
- Abstract
Here we describe clinicopathologic features of Ebola virus disease in pregnancy. One woman infected with Sudan virus in Gulu, Uganda, in 2000 had a stillbirth and survived, and another woman infected with Bundibugyo virus had a live birth with maternal and infant death in Isiro, the Democratic Republic of the Congo in 2012. Ebolavirus antigen was seen in the syncytiotrophoblast and placental maternal mononuclear cells by immunohistochemical analysis, and no antigen was seen in fetal placental stromal cells or fetal organs. In the Gulu case, ebolavirus antigen localized to malarial parasite pigment-laden macrophages. These data suggest that trophoblast infection may be a mechanism of transplacental ebolavirus transmission.
- Subjects
EBOLA virus disease; PREGNANCY complications; IMMUNOSTAINING; INFANT anatomy; PLACENTAL function tests
- Publication
Journal of Infectious Diseases, 2017, Vol 215, Issue 1, p64
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiw206