We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Advantages of Autologous Platelet-Rich Fibrin Membrane on Gingival Crevicular Fluid Growth Factor Levels and Periodontal Healing: A Randomized Split-Mouth Clinical Study.
- Authors
Arabacı, Taner; Kose, Oguz; Albayrak, Mevlut; Cicek, Yasin; Kizildag, Alper; Arabacı, Taner
- Abstract
<bold>Background: </bold>This study evaluates contributions of platelet-rich fibrin (PRF) combined with conventional flap surgery on growth factor levels in gingival crevicular fluid (GCF) and periodontal healing.<bold>Methods: </bold>Twenty-six patients (52 sites) with chronic periodontitis were treated either with autologous PRF with open flap debridement (OFD+PRF) or OFD alone. Growth factor levels in GCF at baseline and 2, 4, and 6 weeks after surgery were analyzed, and clinical parameters such as probing depth (PD), relative clinical attachment level (rCAL), and gingival margin level (GML) at baseline and 9 months after surgery were measured.<bold>Results: </bold>Mean PD reduction and rCAL gain were significantly greater in OFD+PRF sites than in OFD sites. Mean GML change was -0.38 + 0.10 mm in OFD sites and 0.11 + 0.08 mm in the test group; difference between the two groups was statistically significant (P <0.05). Both groups demonstrated increased expression levels of fibroblast growth factor-2, transforming growth factor-β1, and platelet-derived growth factor-BB at 2 weeks compared with baseline, followed by reductions at 4 and 6 weeks. The OFD+PRF group showed significantly higher growth factor levels compared with the OFD group at 2 and 4 weeks.<bold>Conclusion: </bold>PRF membrane combined with OFD provides significantly higher GCF concentrations of angiogenic biomarkers for ≈2 to 4 weeks and better periodontal healing in terms of conventional flap sites.
- Subjects
GINGIVAL fluid; PLATELET-rich fibrin; PERIODONTAL disease treatment; WOUND healing; SURGICAL flaps; FIBROBLAST growth factor 2; BIOLOGICAL membranes; VASCULAR endothelial growth factors
- Publication
Journal of Periodontology, 2017, Vol 88, Issue 8, p771
- ISSN
0022-3492
- Publication type
journal article
- DOI
10.1902/jop.2017.160485