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- Title
Estimation of Bone Loss Biomarkers as a Diagnostic Tool for Peri-Implantitis.
- Authors
Rakic, Mia; Struillou, Xavier; Petkovic‐Curcin, Aleksandra; Matic, Smiljana; Canullo, Luigi; Sanz, Mariano; Vojvodic, Danilo
- Abstract
Background: The aims of this study are to estimate the profile of bone loss biomarkers in peri-implant tissues and to identify potential prognostic biomarkers of peri-implantitis. Methods: Peri-implant crevicular fluid samples collected from 164 participants (52 patients with peri-implantitis, 54 with mucositis, and 58 with healthy peri-implant tissues) were analyzed using enzyme-linked immunosorbent assays to evaluate concentrations of the receptor activator of nuclear factor-κB (RANK), soluble RANK ligand (sRANKL), osteoprotegerin (OPG), cathepsin-K, and sclerostin. Results: Concentrations of RANK, sRANKL, OPG, and sclerostin were significantly increased in patients with peri-implantitis compared with patients with healthy peri-implant tissues. Comparisons between peri-implantitis and mucositis demonstrated significantly higher values of sclerostin in peri-implantitis samples. Comparisons between mucositis and healthy peri-implant tissues showed significantly increased levels of RANK and cathepsin-K in mucositis. Conclusion: These results are suggestive of a role of sRANKL, OPG, and sclerostin as prognostic biomarkers in peri-implantitis.
- Subjects
PERI-implantitis; DENTAL implants; BIOMARKERS; NF-kappa B; LIGANDS (Biochemistry)
- Publication
Journal of Periodontology, 2014, Vol 85, Issue 11, p1566
- ISSN
0022-3492
- Publication type
Article
- DOI
10.1902/jop.2014.140069