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- Title
The protein encoded by the functional steroid receptor RNA activator is a new modulator of ER alpha transcriptional activity
- Authors
Chooniedass-Kothari, Shilpa; Vincett, Daniel; Yan, Yi; Cooper, Charlton; Hamedani, Mohammad K.; Myal, Yvonne; Leygue, Etienne
- Abstract
Abstract: The steroid receptor RNA activator gene (SRA1) encodes for a functional RNA (SRA) as well as a protein (SRAP). While several groups reported on SRA-RNA mechanism of action, SRAP exact function remains to be elucidated, mainly due to a lack of studies investigating the function of the protein independently of its RNA counterpart. Using two independent models to examine its specific functions, SRAP was found to enhance estrogen receptor alpha activity in a ligand and response-element dependent manner. Our data therefore suggest that both transcript and protein products of the SRA1 gene co-modulate the transcriptional activity of steroid receptors.
- Subjects
STEROID receptors; RNA; ESTROGEN receptors; TRANSCRIPTION factors; LIGANDS (Biochemistry); GENETICS
- Publication
FEBS Letters, 2010, Vol 584, Issue 6, p1174
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2010.02.024