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- Title
Role of sestrin2 in peroxide signaling in macrophages
- Authors
Essler, Silke; Dehne, Nathalie; Brüne, Bernhard
- Abstract
Abstract: Reactive oxygen species not only serve as signaling molecules, they also contribute to oxidative stress and cell damage. The thioredoxin and glutaredoxin systems form along with peroxiredoxins a precisely regulated defense system to maintain the cellular redox homeostasis. There is evidence that nitric oxide (NO) protects cells from oxidative stress by preventing inactivation of peroxiredoxins by sulfinylation. Here we demonstrate that NO and hypoxia upregulate Sestrin2 by HIF-1-dependent and additional mechanisms and that Sestrin2 contributes to preventing peroxiredoxins from sulfinylation. We conclude that Sestrin2 plays a role in peroxide defense as a reductase for peroxiredoxins.
- Subjects
PEROXIDES; HYPOXEMIA; MACROPHAGES; SUPEROXIDE dismutase; OXIDATIVE stress; THIOREDOXIN; GLUTAREDOXIN; HOMEOSTASIS; CELLULAR signal transduction; PATHOLOGICAL physiology
- Publication
FEBS Letters, 2009, Vol 583, Issue 21, p3531
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2009.10.017