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- Title
A third functional isoform enriched in mushroom body neurons is encoded by the Drosophila 14-3-3ζ gene
- Authors
Messaritou, Georgia; Leptourgidou, Flora; Franco, Maribel; Skoulakis, Efthimios M.C.
- Abstract
Abstract: 14-3-3 Proteins are highly conserved across eukaryotes, typically encoded by multiple genes in most species. Drosophila has only two such genes, 14-3-3ζ (leo), encoding two isoforms LEOI and LEOII, and 14-3-3ε. We report a bona fide third functional isoform encoded by leo divergent from the other two in structurally and functionally significant areas, thus increasing 14-3-3 diversity in Drosophila. Furthermore, we used a novel approach of spatially restricted leo abrogation by RNA-interference and revealed differential LEO distribution in adult heads, with LEOIII enrichment in neurons essential for learning and memory in Drosophila.
- Subjects
NEURONS; DROSOPHILA genetics; PROTEINS; EUKARYOTIC cells; GENETIC code; NERVOUS system; TISSUES; RNA
- Publication
FEBS Letters, 2009, Vol 583, Issue 17, p2934
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2009.08.003