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- Title
Suppression of the ecdysteroid-triggered growth arrest by a novel Drosophila membrane steroid binding protein
- Authors
Fujii-Taira, Ikuko; Yamaguchi, Shinji; Iijima, Ryoko; Natori, Shunji; Homma, Koichi J.
- Abstract
Abstract: Ecdysteroid is a crucial steroid hormone in insects, especially during metamorphosis. Here, we show that the Drosophila membrane steroid binding protein (Dm_MSBP) is a novel structural homolog of the vertebrate membrane-bound receptor component for progesterone. Dm_MSBP exhibited binding affinity to ecdysone when expressed on the cell surface of Drosophila S2 cells. In S2 cells, the stable overexpression of Dm_MSBP suppressed the growth arrest triggered by 20-hydroxyecdysone and prevented the temporal activation of extracellular signal-regulated kinase proteins. These results suggest that Dm_MSBP is a membranous suppressor to ecdysteroid and blocks the signaling by binding it in extracellular fluid.
- Subjects
ECDYSTEROIDS; STEROID-binding proteins; INSECT metamorphosis; MEMBRANE proteins; CHEMICAL inhibitors; DROSOPHILA; PROGESTERONE; ECDYSONE
- Publication
FEBS Letters, 2009, Vol 583, Issue 4, p655
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2008.12.056