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- Title
Robustness analysis of cellular memory in an autoactivating positive feedback system
- Authors
Cheng, Zhang; Liu, Feng; Zhang, Xiao-Peng; Wang, Wei
- Abstract
Abstract: Cellular memory is a ubiquitous phenomenon in cell biology. Using numerical simulation and theoretical analysis, we explored the robustness of cellular memory to intrinsic noise in a transcriptional positive feedback system. Without noise, the system could create two stable steady states and function as a memory module. Memory robustness index and mean first-passage time were used to quantify the robustness of memory. Large cell size and strong cooperativity in binding enhanced memory storage remarkably. Adding a second positive feedback loop improved persistent memory significantly, whereas including a negative one destabilized memory storage. These are consistent with experimental observations. We interpret why positive feedback loops are actively involved in epigenetic memory from a dynamical systems perspective.
- Subjects
SYSTEMIC memory hypothesis; CYTOLOGY; SIMULATION methods &; models; FEEDBACK control systems; CELL physiology
- Publication
FEBS Letters, 2008, Vol 582, Issue 27, p3776
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2008.10.005