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- Title
Rapamycin reduces VEGF expression in retinal pigment epithelium (RPE) and inhibits RPE-induced sprouting angiogenesis in vitro
- Authors
Stahl, A.; Paschek, L.; Martin, G.; Gross, N.J.; Feltgen, N.; Hansen, L.L.; Agostini, H.T.
- Abstract
Abstract: Anti-VEGF treatment has become accepted first-line treatment for choroidal neovascularisation (CNV) in age-related macular degeneration. However, VEGF-inhibition does not always lead to sustained CNV-reduction. In this study, the effect of rapamycin was superior to VEGF-inhibition in a co-culture assay of endothelial cells (ECs) and retinal pigment epithelium (RPE). Rapamycin reduced EC sprouting in groups that did not respond to anti-VEGF treatment. Rapamycin did not induce EC apoptosis, but reduced both VEGF-production in RPE and the responsiveness of ECs to stimulation. Rapamycin might therefore be a therapeutic option for CNV patients that do not respond sufficiently to the established anti-VEGF treatments.
- Subjects
NEOVASCULARIZATION; RETINAL degeneration; RESPONSE inhibition; RHODOPSIN; EPITHELIUM; RAPAMYCIN; APOPTOSIS
- Publication
FEBS Letters, 2008, Vol 582, Issue 20, p3097
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2008.08.005