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- Title
Fluctuation of the SP/non-SP phenotype in the C6 glioma cell line
- Authors
Platet, Nadine; Mayol, Jean-François; Berger, François; Hérodin, Francis; Wion, Didier
- Abstract
Abstract: Using the C6 glioma cell as a paradigm, we found that (i) the clonogenicity of C6 cells is several orders of magnitude higher than the percentage of SP cells; (ii) non-SP cells are able to generate SP cells, and conversely SP cells generate non-SP cells; (iii) non-SP sorted cells behave as tumorigenic cells. Hence, in C6 cells cultured in serum-containing medium, SP cells can be generated from non-SP cells. This dynamic equilibrium explains in C6 cells the maintenance of the SP phenotype with cell passaging and demonstrates the existence of tumorigenic non-SP cells.
- Subjects
CELLS; SERUM; BLOOD plasma; GENETICS
- Publication
FEBS Letters, 2007, Vol 581, Issue 7, p1435
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2007.02.071