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- Title
Cadmium activates CaMK-II and initiates CaMK-II-dependent apoptosis in mesangial cells
- Authors
Liu, Ying; Templeton, Douglas M.
- Abstract
Abstract: Cadmium is a toxic metal that initiates both mitogenic responses and cell death. We show that Cd2+ increases phosphorylation and activity of Ca2+/calmodulin-dependent protein kinase II (CaMK-II) in mesangial cells, in a concentration-dependent manner. Activation is biphasic with peaks at 1–5min and 4–6h. Cadmium also activates Erk, but this appears to be independent of CaMK-II. At 10–20μM, Cd2+ initiates apoptosis in 25–55% of mesangial cells by 6h. Inhibition of CaMK-II, but not of Erk, suppresses Cd2+-induced apoptosis. We conclude that activation of CaMK-II by Cd2+ contributes to apoptotic cell death, independent of Erk activation.
- Subjects
CELL death; CADMIUM; APOPTOSIS; PHOSPHORYLATION
- Publication
FEBS Letters, 2007, Vol 581, Issue 7, p1481
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2007.03.003