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- Title
High cholesterol diet induces tau hyperphosphorylation in apolipoprotein E deficient mice
- Authors
Rahman, Atiqur; Akterin, Susanne; Flores-Morales, Amilcar; Crisby, Milita; Kivipelto, Miia; Schultzberg, Marianne; Cedazo-Mínguez, Angel
- Abstract
Abstract: We analysed the effects of high cholesterol (HC) intake and reduced apolipoprotein E (apoE) activity on tau phosphorylation and on the activities of the major tau kinases and phosphatases in brains from wild-type and apoE-knockout (apoEKO) mice. We show that HC diet potently induced intraneuronal accumulation of hyperphosphorylated tau in apoEKO mice, as well as upregulation of several tau kinases, without affecting tau phosphatases. Our results suggest an interaction between dietary and genetic factors in the development of tauopathies, which can be relevant in humans, where the apoE4 isoform could have a lack of function as compared to other isoforms.
- Subjects
APOLIPOPROTEIN E; LOW-cholesterol diet; APOLIPOPROTEINS; CHEMICAL reactions
- Publication
FEBS Letters, 2005, Vol 579, Issue 28, p6411
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2005.10.024