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- Title
Oxidative imbalance and cathepsin D changes as peripheral blood biomarkers of Alzheimer disease: A pilot study
- Authors
Straface, Elisabetta; Matarrese, Paola; Gambardella, Lucrezia; Vona, Rosa; Sgadari, Antonio; Silveri, Maria Caterina; Malorni, Walter
- Abstract
Abstract: Markers of oxidative stress in peripheral blood from patients with Alzheimer disease (AD) were analyzed. Thirty-three AD patients were recruited. Plasma antioxidant power (AOP), plasma Cystatin C as well as Cathepsin D in PBL were evaluated. We found that the AOP levels were significantly decreased in AD patients if compared to healthy donors, while the plasma level of Cystatin C was significantly higher. Importantly, a significantly decreased expression of Cathepsin D in PBL was also observed. These results suggest that oxidative imbalance in the peripheral blood of AD patients could mirror oxidative changes previously described in the central nervous system.
- Subjects
ALZHEIMER'S patients; PARKINSON'S disease; ALZHEIMER'S disease; MAGNETIC resonance imaging
- Publication
FEBS Letters, 2005, Vol 579, Issue 13, p2759
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2005.03.094