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- Title
Apigenin suppresses the expression of VEGF, an important factor for angiogenesis, in endothelial cells via degradation of HIF-1α protein
- Authors
Osada, Mayuko; Imaoka, Susumu; Funae, Yoshihiko
- Abstract
Apigenin, a plant-derived flavone, is a potent inhibitor of cell proliferation and angiogenesis, but the mechanisms leading to the pathological anti-angiogenic effects of apigenin are still unclear. In this study, we found that apigenin inhibited the hypoxia-induced expression of vascular endothelial growth factor (VEGF) mRNA in human umbilical artery endothelial cells. Apigenin also suppressed the expression of erythropoietin mRNA, which is a typical hypoxia-inducible gene, via the degradation of hypoxia-inducible factor 1 (HIF-1) α. We investigated the effect of apigenin on the interaction of HIF-1α with heat shock protein 90 (Hsp90), which is reported to be important for the stabilization of HIF-1α, and found that VEGF expression was inhibited via degradation of HIF-1α through interference with the function of Hsp90.
- Subjects
NEOVASCULARIZATION; ENDOTHELIUM; CELLS; PROTEINS
- Publication
FEBS Letters, 2004, Vol 575, Issue 1-3, p59
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2004.08.036