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- Title
Duodenal-Jejunal Bypass Ameliorates Type 2 Diabetes Mellitus by Activating Insulin Signaling and Improving Glucose Utilization in the Brain.
- Authors
Li, Na; Yan, Qing-Tao; Jing, Qi; Pan, Rui-Yan; Wang, Huai-Jie; Jiang, Bin; Li, Xian-Jun; Wang, Yi; Dong, Jun-Hong; Wang, Xue-Jian; Zhang, Mei-Jia; Meng, Qing-Guo; Li, Xiang-Zhen; Liu, Zhi-Jun; Gao, Zhi-Qin; Qu, Mei-Hua
- Abstract
Background: Duodenal-jejunal bypass (DJB) can dramatically improve type 2 diabetes independent of weight loss and food restriction. Increasing evidence has demonstrated that brain insulin signaling plays an important role in the pathophysiology of type 2 diabetes. This study explores whether the antidiabetic effect of DJB is involved in brain insulin signaling activation and brain glucose utilization. Methods: A diabetic rat model was established by high-fat and high-glucose diet. DJB or sham surgery was performed in diabetic rats. 18F-FDG PET scanning was used to detect glucose uptake in different organs, particularly in the brain. The levels of glucose transporters, glucose utilization-related proteins (HK1 and PFK2), insulin, and insulin signaling pathway-related proteins (InsR, IRS1/2, PI3K, and p-Akt) in the brain tissues were evaluated and analyzed. Results: The results showed that DJB significantly improved basal glycemic parameters and reversed the decreasing glucose uptake in the brains of type 2 diabetic rats. DJB significantly increased not only the expression levels of brain insulin, IRS1/2, PI3K, and p-Akt but also the levels of the glucose utilization enzymes HK1 and PFK2 in the brain. Conclusion: These results indicate that enhanced brain insulin signaling transduction and brain glucose utilization play important roles in the antidiabetic effect of DJB.
- Subjects
TYPE 2 diabetes; GASTRIC bypass; INSULIN; GLUCOSE transporters; GLUCOSE; BRAIN
- Publication
Obesity Surgery, 2020, Vol 30, Issue 1, p279
- ISSN
0960-8923
- Publication type
Article
- DOI
10.1007/s11695-019-04153-3