We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
SECRETING OVARIAN LEYDIG CELL TUMOR WITH COMPLEX CLINICAL FEATURES: VIRILIZING SYNDROME, POLYGLOBULIA, HYPERTENSION, DYSLIPIDEMIA AND UTERINE FIBROMATOSIS.
- Authors
Ghervan, C. M. V.; Nemes, C.; Muresan, D.; Crisan, D.; Ghervan, L.
- Abstract
Background. Virilizing syndrome in a postmeno-pausal woman is a concerning matter, raising the suspicion of androgen-secreting tumour. Case Report. A 65 years old woman presented with severe virilization features evolving rapidly over 4 years, accompanied by: severe polyglobulia, severe hypertension, dyslipidemia and uterine fibromatosis compressing both ureters, producing first degree hydroureteronephrosis. The hormonal dosages showed very high levels of both testosterone (15.5 ng/mL) and estradiol (299 pg/mL), meanwhile DHEAS level was normal, indicating an ovarian pathological secretion. The endovaginal ultrasound and computed tomography scan revealed an enlarged right ovary of 5.5/2.8 cm. A total hysterectomy and bilateral oophorectomy was performed. Pathological examination confirmed the diagnosis of right ovarian hilum Leydig cell tumour. After surgery, the testosterone and estradiol levels normalized (concordant to the age and menopausal status), the virilizing syndrome progressively improved and polyglobulia, hypertension and dyslipidemia remitted showing their secondary etiology. Conclusion. We present a very rare case of secreting ovarian Leydig cell tumour in a postmenopausal woman, showing besides the virilizing syndrome, four unusual features: severe polyglobulia, due to androgen excess, severe hypertension and dyslipidemia, all remitted after tumour removal, and severe compressive uterine fibromatosis that was the consequence of the estrogen excess.
- Subjects
LEYDIG cell tumors; POSTMENOPAUSE; ENDOCRINOLOGY
- Publication
Acta Endocrinologica (1841-0987), 2015, Vol 11, Issue 3, p381
- ISSN
1841-0987
- Publication type
Article
- DOI
10.4183/aeb.2015.381