We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Functional implication for myelin regeneration in recovery from ischaemic stroke.
- Authors
Vagionitis, Stavros; Káradóttir, Ragnhildur Thóra
- Abstract
This scientific commentary discusses the role of myelin regeneration in recovery from ischemic stroke. Ischemic stroke causes damage to both gray and white matter, leading to cellular death and loss of brain function. While the effects of ischemia on glial function and myelin have been extensively studied, the role of myelin in recovery after stroke has received less attention. The authors of this study used post-mortem tissue and animal models to evaluate the extent of myelin damage, the functional implications of myelin loss and repair, and the possibility of promoting myelin regeneration for improved outcomes. They found that myelin regeneration can occur in ischemic lesions, but to a lesser extent than in other conditions such as multiple sclerosis. Promoting myelin regeneration may be a key therapeutic strategy for improving functional outcomes after stroke.
- Subjects
ISCHEMIC stroke; MYELIN; NERVOUS system regeneration; OLIGODENDROGLIA
- Publication
Brain: A Journal of Neurology, 2024, Vol 147, Issue 4, p1118
- ISSN
0006-8950
- Publication type
Article
- DOI
10.1093/brain/awae080