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- Title
Role of Calcium Channels in Congenital Heart Block.
- Authors
Karnabi, E.; Boutjdir, M.
- Abstract
Congenital heart block (CHB) is a conduction abnormality that affects hearts of foetuses and/or newborn to mothers with autoantibodies reactive with the intracellular soluble ribonucleoproteins 48-kD La, 52-kD Ro and 60-kD Ro. CHB carries substantial mortality and morbidity, with more than 60% of affected children requiring lifelong pacemakers. Several hypotheses have been proposed to explain the pathogenesis of CHB. These can be grouped under three main hypotheses: Apoptosis, Serotoninergic and Ca channel hypothesis. Here, we discuss these hypotheses and provide recent scientific thinking that will most likely dominate the future of this field of research.
- Subjects
HEART diseases; ION channels; CELL death; AUTOANTIBODIES; APOPTOSIS
- Publication
Scandinavian Journal of Immunology, 2010, Vol 72, Issue 3, p226
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.2010.02439.x