We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation.
- Authors
Korn, Thomas; Reddy, Jayagopala; Gao, Wenda; Bettelli, Estelle; Awasthi, Amit; Petersen, Troels R; Bäckström, B Thomas; Sobel, Raymond A; Wucherpfennig, Kai W; Strom, Terry B; Oukka, Mohamed; Kuchroo, Vijay K
- Abstract
Treatment with ex vivo–generated regulatory T cells (T-reg) has been regarded as a potentially attractive therapeutic approach for autoimmune diseases. However, the dynamics and function of T-reg in autoimmunity are not well understood. Thus, we developed Foxp3gfp knock-in (Foxp3gfp.KI) mice and myelin oligodendrocyte glycoprotein (MOG)35–55/IAb (MHC class II) tetramers to track autoantigen-specific effector T cells (T-eff) and T-reg in vivo during experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis. MOG tetramer–reactive, Foxp3+ T-reg expanded in the peripheral lymphoid compartment and readily accumulated in the central nervous system (CNS), but did not prevent the onset of disease. Foxp3+ T cells isolated from the CNS were effective in suppressing naive MOG-specific T cells, but failed to control CNS-derived encephalitogenic T-eff that secreted interleukin (IL)-6 and tumor necrosis factor (TNF). Our data suggest that in order for CD4+Foxp3+ T-reg to effectively control autoimmune reactions in the target organ, it may also be necessary to control tissue inflammation.
- Subjects
T cells; IMMUNOLOGIC diseases; MYELIN proteins; CENTRAL nervous system; MULTIPLE sclerosis; TUMOR necrosis factors
- Publication
Nature Medicine, 2007, Vol 13, Issue 4, p423
- ISSN
1078-8956
- Publication type
Article
- DOI
10.1038/nm1564