We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Autoimmunity and apoptosis: refusing to go quietly.
- Authors
Bratton, Donna L; Henson, Peter M
- Abstract
This article presents information regarding autoimmunity and apoptosis. After a cell undergoes apoptosis, it is recognized and engulfed by neighboring tissue cells or professional phagocytes. This removal is highly efficient and normally antiinflammatory. Apoptosis almost always increases oxidant stress in cells, and oxidation of the dying cell's membrane lipids may provide important recognition signals for scavenger receptors on the phagocyte. Three newly elaborated oxidized PC species, along with lyso-PC, accumulated in mouse thymocytes undergoing apoptosis in response to dexamethasone.
- Subjects
APOPTOSIS; CELLS; AUTOANTIBODIES; AUTOIMMUNITY; IMMUNE system; STEROIDS
- Publication
Nature Medicine, 2005, Vol 11, Issue 1, p26
- ISSN
1078-8956
- Publication type
Article
- DOI
10.1038/nm0105-26