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- Title
A reappraisal of cholangiocarcinoma in patient with hepatolithiasis.
- Authors
Chen, Miin-Fu; Jan, Yi-Yin; Wang, Chia-Siu; Hwang, Tsann-Long; Jeng, Long-Bing; Chen, Shin-Cheh; Chen, Tong-Jong; Chen, M F; Jan, Y Y; Wang, C S; Hwang, T L; Jeng, L B; Chen, S C; Chen, T J
- Abstract
<bold>Background: </bold>Hepatolithiasis associated with cholangiocarcinoma is not often encountered. During the past 3 years, an increased incidence of patients with hepatolithiasis associated with cholangiocarcinoma was noted. Data were needed to reliably determine the incidence of this disease.<bold>Methods: </bold>Data concerning the relationship between cholangiocarcinoma and hepatolithiasis are presented. The treatment modalities and factors that influence long-term survival are discussed.<bold>Results: </bold>The overall incidence of cholangiocarcinoma in association with hepatolithiasis was 5.0% (55 in 1105). Before 1987, 65% of cholangiocarcinoma in association with hepatolithiasis was diagnosed postoperatively. After 1987, the incidence of accurate preoperative diagnosis increased (22.8%), and in most of the other instances (62.8%), the diagnosis was made at laparotomy. Surgical procedures consisted of common bile duct exploration with T-tube drainage (100%) and hepatectomy (38.2%). Mortality for patients who underwent surgery was 5.4%; they died of recurrent cholangitis. The overall median survival time of patients with cholangiocarcinoma in association with hepatolithiasis was 10.4 months; the 1-, 2-, and 4-year cumulative survival rates were 30.0%, 12.7%, and 3.6%, respectively. Patients with hepatectomy or the presence of mucobilia had better survival rates (P < 0.05).<bold>Conclusions: </bold>The overall incidence of hepatolithiasis associated with cholangiocarcinoma was 5%. In most patients with cholangiocarcinoma in association with hepatolithiasis, diagnosis can be made preoperatively and at laparotomy. Patients with hepatectomy or presence of mucobilia had better survival rates.
- Publication
Cancer (0008543X), 1993, Vol 71, Issue 8, p2461
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19930415)71:8<2461::AID-CNCR2820710806>3.0.CO;2-7