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- Title
Molecular Analysis of Household Transmission of Giardia lamblia in a Region of High Endemicity in Peru.
- Authors
Cooper, Margarethe A.; Sterling, Charles R.; Gilman, Robert H.; Cama, Vitaliano; Ortega, Ynes; Adam, Rodney D.
- Abstract
Background. Giardia lamblia is ubiquitous in multiple communities of nonindustrialized nations. Genotypes A1, A2, and B (Nash groups 1, 2, and 3, respectively) are found in humans, whereas genotypes C and D are typically found in dogs. However, genotypes A and B have occasionally been identified in dogs. Methods. Fecal Giardia isolates from 22 families and their dogs, living in Pampas de San Juan, were collected over 7 weeks in 2002 and 6 weeks in 2003. Samples were genotyped, followed by sequencing and haplotyping of many of these isolates by using loci on chromosomes 3 and 5. Results. Human infections were all caused by isolates of genotypes A2 and B. Human coinfections with genotypes A2 and B were common, and the reassortment pattern of different subtypes of A2 isolates supports prior observations that suggested recombination among genotype A2 isolates. All dogs had genotypes C and/or D, with one exception of a dog with a mixed B/D genotype infection. Conclusions. In a region of high endemicity where infected dogs and humans constantly commingle, different genotypes of Giardia are almost always found in dogs and humans, suggesting that zoonotic transmission is very uncommon.
- Subjects
PERU; GIARDIA lamblia; INFECTION; GENETIC research; GENOTYPE-environment interaction
- Publication
Journal of Infectious Diseases, 2010, Vol 202, Issue 11, p1713
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/657142