We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Hormonal, Metabolic, and Inflammatory Profiles and Endometrial Cancer Risk Within the EPIC Cohort—A Factor Analysis.
- Authors
Dossus, Laure; Lukanova, Annekatrin; Rinaldi, Sabina; Allen, Naomi; Cust, Anne E.; Becker, Susen; Tjonneland, Anne; Hansen, Louise; Overvad, Kim; Chabbert-Buffet, Nathalie; Mesrine, Sylvie; Clavel-Chapelon, Francoise; Teucher, Birgit; Chang-Claude, Jenny; Boeing, Heiner; Drogan, Dagmar; Trichopoulou, Antonia; Benetou, Vasiliki; Bamia, Christina; Palli, Domenico
- Abstract
A “Western” lifestyle characterized by physical inactivity and excess weight is associated with a number of metabolic and hormonal dysregulations, including increased circulating estrogen levels, hyperinsulinemia, hyperglycemia, and chronic inflammation. The same hormonal and metabolic axes might mediate the association between this lifestyle and the development of endometrial cancer. Using data collected within the European Prospective Investigation into Cancer and Nutrition (EPIC), a prospective cohort study carried out in 10 European countries during 1992–2000, we conducted a factor analysis to delineate important components that summarize the variation explained by a set of biomarkers and to examine their association with endometrial cancer risk. Prediagnostic levels of testosterone, androstenedione, dehydroepiandrosterone sulfate, sex hormone-binding globulin, estrone, estradiol, C-peptide, insulin-like growth factor-binding proteins 1 and 2, adiponectin, high- and low-density lipoprotein cholesterol, glucose, triglycerides, tumor necrosis factor (TNF) α, soluble TNF receptors 1 and 2, C-reactive protein, interleukin-6, and interleukin-1 receptor antagonist were measured in 233 incident endometrial cancer cases and 446 matched controls. Factor analysis identified 3 components associated with postmenopausal endometrial cancer risk that could be labeled “insulin resistance/metabolic syndrome,” “steroids,” and “inflammation” factors. A fourth component, “lipids,” was not significantly associated with endometrial cancer. In conclusion, besides the well-known associations of risk with sex hormones and insulin-regulated physiological axes, our data further support the hypothesis that inflammation factors play a role in endometrial carcinogenesis.
- Subjects
EUROPE; ENDOMETRIAL tumors; BIOMARKERS; BLOOD testing; COMPARATIVE studies; CONFIDENCE intervals; STATISTICAL correlation; EPIDEMIOLOGY; FACTOR analysis; HORMONES; INFLAMMATION; INSULIN resistance; LONGITUDINAL method; METABOLISM; RESEARCH funding; SEX distribution; STEROIDS; DATA analysis; SECONDARY analysis; POSTMENOPAUSE; DESCRIPTIVE statistics; TUMOR risk factors
- Publication
American Journal of Epidemiology, 2013, Vol 177, Issue 8, p787
- ISSN
0002-9262
- Publication type
Article
- DOI
10.1093/aje/kws309