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- Title
Alterations in the C-Terminal Region of the HIV-1 Accessory Gene vpr Do Not Confer Clinical Advantage to Subjects Receiving Nucleoside to Subjects Receiving Nucleoside.
- Authors
Cavert, Winston; Webb, Chui-Ho; Balfour Jr., Henry H.
- Abstract
The C terminus of the human immunodeficiency virus type 1 (HIV-1) accessory protein vpr acts in viral cell cycle arrest, nuclear localization, and apoptosis. Polymorphisms in this region are described in series of long-term nonprogression cases. We determined vpr sequences of archived baseline specimens from 96 participants in a historical trial of single- versus double-nucleoside reverse-transcriptase inhibitors. These sequences were then analyzed by study-entry and -outcome characteristics such as baseline absolute CD4+ T cell count, prior treatment, CD4+ T cell response, and clinical endpoints. Frequency of C-terminal mutations did not correlate to any measures of disease intensity. Changes in that portion of vpr did not attenuate disease.
- Subjects
HIV; LYMPHOCYTES; T cells; CELL death; IMMUNODEFICIENCY; AIDS; LOCOMOTION; APOPTOSIS
- Publication
Journal of Infectious Diseases, 2004, Vol 189, Issue 12, p2181
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/420788