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- Title
A clinical drug library screen identifies astemizole as an antimalarial agent.
- Authors
Chong, Curtis R.; Xiaochun Chen; Lirong Shi; Liu, Jun O.; Sullivan, David J.
- Abstract
The high cost and protracted time line of new drug discovery are major roadblocks to creating therapies for neglected diseases. To accelerate drug discovery we created a library of 2,687 existing drugs and screened for inhibitors of the human malaria parasite Plasmodium falciparum. The antihistamine astemizole and its principal human metabolite are promising new inhibitors of chloroquine-sensitive and multidrug-resistant parasites, and they show efficacy in two mouse models of malaria.
- Subjects
ANTIMALARIALS; PLASMODIUM falciparum; DRUG development; ASTEMIZOLE; ANTIHISTAMINES; DRUG resistance in microorganisms
- Publication
Nature Chemical Biology, 2006, Vol 2, Issue 8, p415
- ISSN
1552-4450
- Publication type
Article
- DOI
10.1038/nchembio806