We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Osteogenic Potential of Brown Seaweed Extracts.
- Authors
Walsh, Pamela J.; McGrath, Susan; McKelvey, Steven; Ford, Lauren; Sheldrake, Gary; Clarke, Susan A.
- Abstract
Marine drugs hold significantly more promise than their terrestrial counterparts, which could help to solve the current shortfall in treatments for osteoporosis and other bone related diseases. Fucoxanthin is the main carotenoid found in brown seaweed, and has many perceived health benefits, including potential bone therapeutic properties. This study assessed the osteogenic potential of pure fucoxanthin and crude extracts containing both fucoxanthin and phenolic fractions (also cited to have osteogenic potential) isolated from two intertidal species of brown seaweed, Laminaria digitata and Ascophyllum nodosum. In vitro studies were performed using a human foetal osteoblast cell line (hFOBs) and primary human bone marrow stromal cells (hBMSCs). The results found pure fucoxanthin inhibitory to cell proliferation in hFOBs at higher concentrations, whereas, the crude extracts containing both polyphenols and fucoxanthin showed the ability to scavenge free radicals, which masked this effect. None of the extracts tested showed strong pro-osteogenic effects in either cell type tested, failing to support previously reported positive effects.
- Subjects
MARINE algae; OSTEOPOROSIS treatment; CAROTENOIDS; MESENCHYMAL stem cells; LAMINARIA digitata
- Publication
Marine Drugs, 2019, Vol 17, Issue 3, p141
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md17030141