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- Title
Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites.
- Authors
Wright, Amy E.; Killday, K. Brian; Chakrabarti, Debopam; Guzmán, Esther A.; Harmody, Dedra; McCarthy, Peter J.; Pitts, Tara; Pomponi, Shirley A.; Reed, John K.; Roberts, Bracken F.; Felix, Carolina Rodrigues; Rohde, Kyle H.
- Abstract
A deep-water sponge of the genus Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G was first reported by us in the patent literature and has recently been reported by Hitora et al. from a sponge of the genus Lipastrotheya. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines.
- Subjects
INDOLE alkaloid synthesis; PYRAZINE derivatives; HALICHONDRIIDAE; SPONGES (Invertebrates) biotechnology; CANCER cells
- Publication
Marine Drugs, 2017, Vol 15, Issue 1, p16
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md15010016