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- Title
Histopathological background data of the systemic organs of CLAWN miniature swine with coronary artery stent implantation.
- Authors
Atsushi Isobe; Masako Tasaki; Tomoki Inoue; Hisako Terao; Junko Souba; Kasuke Nagano; Hitomi Hagiwara
- Abstract
The aim of this study was to identify potential changes that could occur during histological evaluations of CLAWN miniature swine, with potential consequences for subsequent experiments. The systemic organs from male and female CLAWN miniature swine (16.3-42.3 months old) that had been used in long-term studies of coronary stent implantation were examined histologically. Commonly observed histopathological findings were testicular/epididymal atrophy, cyst-like follicles in the ovaries, hemosiderin deposition in the spleen, lipofuscin deposition in the proximal tubular epithelia and presence of eosinophilic globules in the Bowman's space and the lumen of the proximal tubules in the kidneys, and cellular infiltration in several organs, including the eyelids, respiratory organs, and digestive tract. However, none of these changes were serious enough to indicate a significant impact on research. In conclusion, this study identified CLAWN miniature swine as a suitable animal model for various experiments.
- Subjects
MINIATURE pigs; SURGICAL stents; CORONARY arteries; HEART blood-vessels; ANIMAL models in research; SURGERY
- Publication
Journal of Toxicologic Pathology, 2017, Vol 30, Issue 1, p25
- ISSN
0914-9198
- Publication type
Article
- DOI
10.1293/tox.2016-0024