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- Title
Toxin genotypes, antibiotic resistance and their correlations in Clostridioides difficile isolated from hospitals in Xi'an, China.
- Authors
Zhang, Sukai; Ma, Chen; Zhang, Haiyue; Zhao, Congcong; Guo, Ruibing; Liu, Jiahao; Wang, Jing; Yuan, Jing; Jia, Kai; Wu, Airong; Chen, Yanjiong; Lei, Jin'e
- Abstract
Background: Clostridioides difficile is the main pathogen of antimicrobial-associated diarrhoea and health care facility-associated infectious diarrhoea. This study aimed to investigate the prevalence, toxin genotypes, and antibiotic resistance of C. difficile among hospitalized patients in Xi'an, China. Results: We isolated and cultured 156 strains of C. difficile, representing 12.67% of the 1231 inpatient stool samples collected. Among the isolates, tcdA + B + strains were predominant, accounting for 78.2% (122/156), followed by 27 tcdA-B + strains (27/156, 17.3%) and 6 binary toxin gene-positive strains. The positive rates of three regulatory genes, tcdC, tcdR, and tcdE, were 89.1% (139/156), 96.8% (151/156), and 100%, respectively. All isolates were sensitive to metronidazole, and the resistance rates to clindamycin and cephalosporins were also high. Six strains were found to be resistant to vancomycin. Conclusion: Currently, the prevalence rate of C. difficile infection (CDI) in Xi'an is 12.67% (156/1231), with the major toxin genotype of the isolates being tcdA + tcdB + cdtA-/B-. Metronidazole and vancomycin were still effective drugs for the treatment of CDI, but we should pay attention to antibiotic management and epidemiological surveillance of CDI.
- Subjects
XI'AN Shi (China); CLOSTRIDIOIDES difficile; DRUG resistance in bacteria; TOXINS; REGULATOR genes; GENOTYPES; CLINDAMYCIN; RIBAVIRIN
- Publication
BMC Microbiology, 2024, Vol 24, Issue 1, p1
- ISSN
1471-2180
- Publication type
Article
- DOI
10.1186/s12866-024-03327-z