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- Title
An extranodal Richter's syndrome presenting with cardiac diffuse large B-cell lymphoma: a case report.
- Authors
Wang, Hua; Yan, Wei-hong; Sun, Jun-jie; Dong, Mei; Zhang, Nan; Liu, Tong; Song, Nian-peng; Zhong, Lin
- Abstract
Background: Richter's syndrome (RS) defines the transformation of chronic lymphocytic leukemia into high-grade lymphoma, which usually involves lymph nodes and bone marrow. Extranodal involvement of the heart is an extremely rare condition. Patients with heart involvement tended to have a low response to chemotherapy and relative poor prognosis. The transformation process of RS is often insidious and nonspecific making it challenging to diagnose. Case presentation: A 64-year-old woman wih a history of chronic lymphocytic leukemia (CLL) presented with intermittent chest pain and was diagnosed with non-ST-elevation myocardial infarction (NSTEMI). However, the contrast enhanced echocardiography revealed a large irregular mass, measuring about 75.4 mm × 37.5 mm, located on the lateral and posterior wall of the right ventricle. Biopsy of the cardiac mass and the results revealed diffuse large B-cell lymphoma. Conclusions: We present a case of a 64-year-old woman with aggressive diffuse large B-cell lymphoma involving the heart. This case could provide some insights in the diagnosis of cardiac lymphoma.
- Subjects
RICHTER syndrome; DIFFUSE large B-cell lymphomas; CHRONIC lymphocytic leukemia; NON-ST elevated myocardial infarction; BONE marrow
- Publication
BMC Cardiovascular Disorders, 2023, Vol 23, Issue 1, p1
- ISSN
1471-2261
- Publication type
Article
- DOI
10.1186/s12872-023-03663-4