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- Title
The Effect of Recombinant Equine Growth Hormone on the Biomechanical Properties of Healing Superficial Digital Flexor Tendons in Horses.
- Authors
Dowling, Bradley A.; Dart, Andrew J.; Hodgson, David R.; Rose, Reuben J.; Walsh, William R.
- Abstract
Objective- To evaluate the effect of recombinant equine growth hormone (rEGH) on the in vitro biomechanical properties of healing superficial digital flexor tendon (SDFT) in horses. Study design- Completely randomized design. Sample population- Twelve Standardbred horses, 3 to 7 years of age, with ultrasonographically normal forelimb SDFT. Methods- One week after induction of collagenase (2,000 U) induced superficial flexor tendonitis, horses were randomly divided into groups of 6. One group was administered intramuscular rEGH (10 μg/kg/day for 1 week, then 20 μg/kg/day for 5 weeks), whereas the other group (control subjects) were administered an equivalent volume of saline (0.9% NaCl) solution. At the end of this 6-week treatment, horses were killed and one forelimb SDFT from each horse was harvested for biomechanical testing under uniaxial tension. Results were analyzed using an unpaired Student's t test; significance was set at
- Publication
Veterinary Surgery, 2002, Vol 31, Issue 4, p320
- ISSN
0161-3499
- Publication type
Article
- DOI
10.1053/jvet.2002.33590